Hi Paul, there is plenty of accommodation around Nong Khai with budgets to suit all prices, but the only hotels that I am aware of that have a safe in the room are the Nong Khai Grand and Mekong Royal, both have internet available and further information and online booking is available on our accommodation listing page:
http://www.nongkhaimap.com/index.php/no ... ation-menuUnfortunately neither are very well located for the nightlife area of town, both have plenty of restaurants surrounding them, but transport will not be an issue from either hotel into town.
There are plenty of other smaller hotels and guesthouses all over the town, but like I mentioned, I don't think any others have safes in the room.